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- Title
The TNFAIP3 polymorphism rs610604 both associates with the risk of psoriasis vulgaris and affects the clinical severity.
- Authors
Zhang, C.; Zhu, K.‐J.; Liu, H.; Quan, C.; Liu, Z.; Li, S.‐J.; Zhu, C.‐Y.; Li, K.‐S.; Fan, Y.‐M.
- Abstract
Background Genome-wide association studies in white and Chinese Han populations have found that the single-nucleotide polymorphism ( SNP) rs610604, at the tumour necrosis factor ( TNF)-α-induced protein 3 ( TNFAIP3) locus, is associated with psoriasis, and is also associated with response to TNF blockade in psoriasis. Aim To examine whether this SNP is also associated with the clinical traits of psoriasis vulgaris ( PV). Methods A hospital-based case-control study was performed, which involved 647 subjects [351 patients with PV and 296 healthy controls ( HC)]. The rs610604 variants were typed using a SNaPshot assay. Results Both the G allele and the dominant model genotype ( GG + GT) of rs610604 were associated with risk of PV ( OR = 1.53; P = 0.01 and OR = 1.68, P < 0.01, respectively). In genotype-phenotype analysis, both the G allele and the GG + GT genotype were also associated with the clinical severity of PV. Severe cases [Psoriasis Area and Severity Index ( PASI) > 6] had a higher frequency of the G allele and the GG + GT genotype compared with mild cases ( PASI ≤ 6) ( OR = 2.03, P = 0.001 and OR = 2.46, P < 0.001, respectively). In addition, rs610604 was significantly associated with almost all of the phenotypes in subphenotype-control analyses. Conclusions SNP rs610604 in the TNFAIP3 locus is associated with the clinical severity of PV in a Chinese Han population.
- Subjects
SKIN diseases; PSORIASIS treatment; TUMOR necrosis factors; SINGLE nucleotide polymorphisms; SEVERITY of illness index
- Publication
Clinical & Experimental Dermatology, 2015, Vol 40, Issue 4, p426
- ISSN
0307-6938
- Publication type
Article
- DOI
10.1111/ced.12536