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- Title
Radial Arm Maze Performance in Rats Following Neonatal Dopamine Depletion.
- Authors
Pearson, David E.; Raskin, Lisa A.; Shaywitz, Bennett A.; Anderson, George M.; Cohen, Donald J.
- Abstract
Neonatal dopamine (DA) depletion produces learning impairments both during development and throughout adulthood in the rat. The present experiment further investigated the memory capabilities of the dopamine-depleted rat by assessing performance La the radial arm maze. Results showed that, following neonatal injection of 6-hydroxydopamine and desmethylimipramine, lesioned rats perperformed more accurately than controls. In this paradigm, DA-depleted rats tended to enter each arm to obtain a food pellet and not enter unbaited, incorrect arms. The difference La performance of control and treated rats could not be accounted for by differences m locomotor activity, body weights, or motivational factors. A computer analysis of the data revealed that DA-depleted animals adopted a strategy of choosing adjacent arms consecutively, which probably accounted for their superior performance. Results are discussed m terms using algorithms versus extra-maze cues to complete the maze following early brain injury.
- Subjects
DOPAMINE; MAZE tests; LEARNING disabilities; RAT behavior; ANIMAL psychology testing; ANIMAL experimentation
- Publication
Developmental Psychobiology, 1984, Vol 17, Issue 5, p505
- ISSN
0012-1630
- Publication type
Article
- DOI
10.1002/dev.420170508