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- Title
Role of Moringa oleifera in regulation of diabetes-induced oxidative stress.
- Authors
Jaiswal, Dolly; Rai, Prashant Kumar; Mehta, Shikha; Chatterji, Sanjukta; Shukla, Surekha; Rai, Devendra Kumar; Sharma, Gaurav; Sharma, Bechan; khair, Shahidul; Watal, Geeta
- Abstract
Abstract: Objective: To evaluate the antioxidant activity of aqueous extract ofMoringa oleifera (M. oleifera) young leaves by in vivo as well as in vitro assays. Methods: In vitro study included estimation of total phenolic, total flavonol, total flavonoid and total antioxidant power (FRAP assay). In addition, in vivo study was done with the identified most effective dose of 200 mg/kg of its lyophilized powder on normal and diabetic rats. Its effect on different oxidative free radical scavenging enzymes,viz, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), lipid peroxide (LPO) contents were measured. Results: Significant increase in activities of SOD, CAT, GST while, a decrease in LPO content was observed. Whereas, total phenolic, flavonoid and flavonol contents in the extract were found to be 120 mg/g of GAE, 40.5 mg/g of QE and 12.12 mg/g of QE, respectively. On the other hand, FRAP assay results ofM. oleifera leaves was (85.00±5.00)μM/g of extract powder. Conclusions: The significant antioxidant activities ofM. oleifera leaves from both in vivo as well as in vitro studies suggests that the regular intake of its leaves through diet can protect normal as well as diabetic patients against oxidative damage.
- Publication
Asian Pacific Journal of Tropical Medicine, 2013, Vol 6, Issue 6, p426
- ISSN
1995-7645
- Publication type
Article
- DOI
10.1016/S1995-7645(13)60068-1