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- Title
14-3-3ε functions as an oncogene in SGC7901 gastric cancer cells through involvement of cyclin E and p27<sup>kip1</sup>.
- Authors
XIAOXIANG GONG; LU YAN; HUAN GU; YIBING MU; GELE TONG; GUIYING ZHANG
- Abstract
Investigation into the highly conserved 14-3-3ε protein has become increasingly important in cell biology due to its involvement in cell survival signaling, cell cycle control and apoptosis. The 14-3-3ε protein has been found to exert an impact on the development of various tumor types. However, the functional role and the possible mechanism of 14-3-3ε in gastric cancer remains to be elucidated. A previous study by our group indicated a negative correlation between 14-3-3ε expression levels and gastric cancer tissue differentiation and a positive correlation between 14-3-3ε expression levels and tumor infiltration, lymph node metastasis and tumor, nodes and metastasis staging. In the present study, 14-3-3ε suppression in the SGC7901 gastric cancer cell line was demonstrated to inhibit cell proliferation in vitro and tumor growth in vivo and the cell cycle-associated proteins cyclin E and p27kip1 may have contributed to this antitumor effect. The present study showed for the first time that reducing the expression of 14-3-3ε may inhibit the proliferation and progression of gastric cancer and inhibition of this protein may provide a potential strategy for gastric cancer therapy in the future.
- Subjects
ONCOGENES; CANCER cells; STOMACH cancer; CYCLIN E; CYTOLOGY; CELL proliferation
- Publication
Molecular Medicine Reports, 2014, Vol 10, Issue 6, p3145
- ISSN
1791-2997
- Publication type
Article
- DOI
10.3892/mmr.2014.2605