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- Title
Protein-Gene Orthology in Baculoviridae : An Exhaustive Analysis to Redefine the Ancestrally Common Coding Sequences.
- Authors
Cerrudo, Carolina Susana; Motta, Lucas Federico; Cuccovia Warlet, Franco Uriel; Lassalle, Fernando Maku; Simonin, Jorge Alejandro; Belaich, Mariano Nicolás
- Abstract
Baculoviruses are entomopathogens that carry large, double-stranded circular DNA genomes and infect insect larvae of Lepidoptera, Hymenoptera and Diptera, with applications in the biological control of agricultural pests, in the production of recombinant proteins and as viral vectors for various purposes in mammals. These viruses have a variable genetic composition that differs between species, with some sequences shared by all known members, and others that are lineage-specific or unique to isolates. Based on the analysis of nearly 300 sequenced genomes, a thorough bioinformatic investigation was conducted on all the baculoviral protein coding sequences, characterizing their orthology and phylogeny. This analysis confirmed the 38 protein coding sequences currently considered as core genes, while also identifying novel coding sequences as candidates to join this set. Accordingly, homology was found among all the major occlusion body proteins, thus proposing that the polyhedrin, granulin and CUN085 genes be considered as the 39th core gene of Baculoviridae.
- Subjects
BIOLOGICAL control of agricultural pests; BACULOVIRUSES; GENETIC vectors; INSECT larvae; RECOMBINANT proteins; BIOLOGICAL control of insects; CIRCULAR DNA; PLANT viruses
- Publication
Viruses (1999-4915), 2023, Vol 15, Issue 5, p1091
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v15051091