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- Title
Clinical Significance of p53 and bcl-2 Protein Coexpression Phenotypes in Molecular Breast Cancer Subtypes of Pre-menopausal and Post-menopausal African-American Women.
- Authors
IHEMELANDU, CHUKWUEMEKA U.; DEWITTY JR., ROBERT L.; LEFFALL JR., ASALLE D.; SURYANARAYANA, SIRAM M.; FREDERICK, WAYNE A.
- Abstract
With the current classification of breast carcinoma into molecular subtypes with distinct prognosis and response to therapy, we sort to assess the clinical significance of p53 and bcl-2 coexpression phenotypes in invasive breast tumors and correlate this to the different molecular breast cancer subtypes in African-American women. We performed a retrospective analysis of data on p53 and bcl-2 expression. Results were correlated to molecular breast cancer subtypes, and clinicopathologic variables of prognostic significance. Our study sample included all African- American women diagnosed with breast cancer from 1998 to 2005. Twenty-seven (27.6%) per cent of cases in our study sample over-expressed p53, whereas 69.3 per cent over-expressed bcl-2 protein. A significant inverse correlation was observed between expression of p53 and bcl-2. Combined analysis of p53 and bcl-2 showed that 53.2 per cent of the tumors displayed p53(-)bcl-2(+) phenotype which was significantly associated with the luminal A subtype, whereas 11.6 per cent displayed the p53(+)bcl-2(-) phenotype which was significantly associated with the basal cell-like and Her-2/neu. Neither p53 expression nor bcl-2 expression individually or in combination were of independent prognostic significance, p53(+)bcl-2(-) phenotype is significantly correlated with the basal cell-like subtype and may be associated with the biologic aggressiveness of this cohort of molecular breast cancer.
- Subjects
P53 protein; BREAST cancer; CANCER patients; AFRICAN American women; CANCER in women; POSTMENOPAUSE
- Publication
American Surgeon, 2009, Vol 75, Issue 9, p776
- ISSN
0003-1348
- Publication type
Article
- DOI
10.1177/000313480907500907