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- Title
Biochemical, Anthropometric and Lifestyle Factors Related with Weight Maintenance after Weight Loss Secondary to a Hypocaloric Mediterranean Diet.
- Authors
de Luis, Daniel Antonio; Izaola, Olatz; Primo, David; Ovalle, Hilda F.; Lopez, Juan Jose; Gomez, Emilia; Ortola, Ana; Aller, Rocio
- Abstract
Background/Aims: The aim of our study was to evaluate the influence of lifestyle factors and molecular biomarkers on the maintenance of the weight lost after a hypocaloric Mediterranean diet. Design: After 3 months on a diet, patients (n = 335) remained with no controlled diet during 3 years and they were revaluated. Results: Using linear regression, in the group of responders, we detected that a positive weight loss at 3 months, serum levels of leptin at 3 months, and each 30 min per week of physical activity were associated with weight loss maintenance. In the model with reduced weight (RW) as dependent variable, a positive weight loss at 3 months was associated with 2.4% RW (95% CI 1.31- 8.11; p = 0.015), each unit of serum leptin levels at 3 months with -0.44% RW (95% CI -0.59 to -0.020; p = 0.007), each basal unit homeostasis model assessment for insulin resistance (HOMA-IR) level with -2.32% (95% CI -13.01 to -0.17; p = 0.040), and each 30 min per week of physical activity with 1.58% RW (95% CI 1.08-2.94; p = 0.020). Conclusion: Obese subjects who are on maintenance weight loss after a dietary intervention appear to have a better initial response during the 3 months intervention, more physical activity at 3 years, and lower basal HOMA-IR and leptin after weight loss than those who regain weight.
- Subjects
REGULATION of body weight; CONFIDENCE intervals; INSULIN resistance; LONGITUDINAL method; PROBABILITY theory; REDUCING diets; REGRESSION analysis; TIME; LEPTIN; LIFESTYLES; PHYSICAL activity; DESCRIPTIVE statistics; MEDITERRANEAN diet
- Publication
Annals of Nutrition & Metabolism, 2018, Vol 71, Issue 3/4, p217
- ISSN
0250-6807
- Publication type
Article
- DOI
10.1159/000484446