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- Title
The role of protein oxidative modification and the cellular redox status in realization of apoptosis of MCF-7 breast adenocarcinoma cells.
- Authors
Shakhristova, E.; Stepovaya, E.; Ryazantseva, N.; Nosareva, O.; Yakushina, V.; Ivanov, V.; Novitsky, V.
- Abstract
The aim of this study was to establish the role of oxidative modification of proteins and redox status in the realization of apoptosis of MCF-7 breast adenocarcinoma cells during cultivation with the SH-group blocker N-ethylmaleimide (NEM) and the SH-group protector 1,4-dithioerythritol (DTE). The activation of apoptosis in MCF-7 breast adenocarcinoma cells was shown to be due to the irreversible modification of redox-sensitive protein molecules. The presence of DTE in the culture medium of cancer cells caused reversible glutathionylation of protein molecules and did not change the number of apoptotic MCF-7 cells.
- Subjects
APOPTOSIS; ADENOCARCINOMA; N-ethylmaleimide; BREAST cancer; OXIDATION-reduction reaction
- Publication
Biology Bulletin, 2016, Vol 43, Issue 5, p385
- ISSN
1062-3590
- Publication type
Article
- DOI
10.1134/S1062359016050095