We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Strains Responsible for Invasive Meningococcal Disease in Patients With Terminal Complement Pathway Deficiencies.
- Authors
Rosain, Jérémie; Hong, Eva; Fieschi, Claire; Vieira Martins, Paula; El Sissy, Carine; Deghmane, Ala-Eddine; Ouachée, Marie; Thomas, Caroline; Launay, David; de Pontual, Loïc; Suarez, Felipe; Moshous, Despina; Picard, Capucine; Taha, Muhamed-Kheir; Frémeaux-Bacchi, Véronique; Martins, Paula Vieira
- Abstract
<bold>Background: </bold>Patients with terminal complement pathway deficiency (TPD) are susceptible to recurrent invasive meningococcal disease (IMD). Neisseria meningitidis (Nm) strains infecting these patients are poorly documented in the literature.<bold>Methods: </bold>We identified patients with TPD and available Nm strains isolated during IMD. We investigated the genetic basis of the different TPDs and the characteristics of the Nm strains.<bold>Results: </bold>We included 56 patients with C5 (n = 8), C6 (n = 20), C7 (n = 18), C8 (n = 9), or C9 (n = 1) deficiency. Genetic study was performed in 47 patients and 30 pathogenic variants were identified in the genes coding for C5 (n = 4), C6 (n = 5), C7 (n = 12), C8 (n = 7), and C9 (n = 2). We characterized 61 Nm strains responsible for IMD in the 56 patients with TPD. The most frequent strains belonged to groups Y (n = 27 [44%]), B (n = 18 [30%]), and W (n = 8 [13%]). Hyperinvasive clonal complexes (CC11, CC32, CC41/44, and CC269) were responsible for 21% of IMD cases. The CC23 predominates and represented 26% of all invasive isolates. Eleven of the 15 clonal complexes identified fit to 12 different clonal complexes belonging to carriage strains.<bold>Conclusions: </bold>Unusual meningococcal strains with low level of virulence similar to carriage strains are most frequently responsible for IMD in patients with TPD.
- Subjects
FRANCE; MENINGOCOCCAL infections; NEISSERIA meningitidis; GENETIC code; MICROBIAL virulence; PATHOGENIC microorganisms; COMPLEMENT (Immunology); IMMUNITY; GENETIC testing; RETROSPECTIVE studies; GRAM-negative aerobic bacteria
- Publication
Journal of Infectious Diseases, 2017, Vol 215, Issue 8, p1331
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jix143