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- Title
Expressed sequence tags from Madagascar periwinkle (Catharanthus roseus)
- Authors
Murata, Jun; Bienzle, Dorothee; Brandle, Jim E.; Sensen, Christoph W.; De Luca, Vincenzo
- Abstract
Abstract: The Madagascar periwinkle (Catharanthus roseus) is well known to produce the chemotherapeutic anticancer agents, vinblastine and vincristine. In spite of its importance, no expressed sequence tag (EST) analysis of this plant has been reported. Two cDNA libraries were generated from RNA isolated from the base part of young leaves and from root tips to select 9824 random clones for unidirectional sequencing, to yield 3327 related sequences and 1696 singletons by cluster analysis. Putative functions of 3663 clones were assigned, from 5023 non-redundant ESTs to establish a resource for transcriptome analysis and gene discovery in this medicinal plant.
- Subjects
CATHARANTHUS roseus; ANTINEOPLASTIC agents; CATHARANTHUS; NUCLEIC acids
- Publication
FEBS Letters, 2006, Vol 580, Issue 18, p4501
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2006.07.020