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- Title
Platelet-activating factor induces matrix metalloproteinase-9 expression through Ca<sup>2+</sup>- or PI3K-dependent signaling pathway in a human vascular endothelial cell line
- Authors
Ko, Hyun-Mi; Kang, Jee-Hae; Choi, Jung-Hwa; Park, Sung Jun; Bai, Suk; Im, Suhn-Young
- Abstract
Abstract: Platelet-activating factor (PAF) augments angiogenesis by promoting the synthesis of a variety of angiogenic factors, via the nuclear factor (NF)-κB activation. Recently, we reported that PAF upregulates MMP-9 expression in a NF-κB-dependent manner. In this study, we investigated the signaling pathway involved in PAF-induced MMP-9 expression in ECV304 cells. Our current data indicate that the Ca2+- or phosphatidylinositol 3-kinase (PI3K)-dependent signaling pathway is necessary for PAF-induced MMP-9 expression. Furthermore, PAF-induced NF-κB activation was blocked by selective inhibitors of Ca2+, PI3K, or extracellular signal-regulated kinase (ERK). Our results suggest that PAF-induced MMP-9 expression, in a NF-κB-dependent manner, is regulated by Ca2+, PI3K and ERK signaling pathways.
- Subjects
PLATELET activating factor; NEOVASCULARIZATION; CALCIUM; METALLOPROTEINASES
- Publication
FEBS Letters, 2005, Vol 579, Issue 28, p6451
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.10.027