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- Title
T-box and homeobox genes from the ctenophore Pleurobrachia pileus: Comparison of Brachyury, Tbx2/3 and Tlx in basal metazoans and bilaterians
- Authors
Martinelli, Cosimo; Spring, Jürg
- Abstract
Abstract: Most animals are classified as Bilateria and only four phyla are still extant as outgroups, namely Porifera, Placozoa, Cnidaria and Ctenophora. These non-bilaterians were not considered to have a mesoderm and hence mesoderm-specific genes. However, the T-box gene Brachyury could be isolated from sponges, placozoans and cnidarians. Here, we describe the first Brachyury and a Tbx2/3 homologue from a ctenophore. In addition, analysing T-box and homeobox genes under comparable conditions in all four basal phyla lead to the discovery of novel T-box genes in sponges and cnidarians and a Tlx homeobox gene in the ctenophore Pleurobrachia pileus . The conservation of the T-box and the homeobox genes suggest that distinct subfamilies with different roles in bilaterians were already split in non-bilaterians.
- Subjects
GENES; HEREDITY; INVERTEBRATES; SPONGES (Invertebrates)
- Publication
FEBS Letters, 2005, Vol 579, Issue 22, p5024
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.08.008