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- Title
Quantitative <sup>99m</sup>Tc-DPD SPECT/CT in patients with suspected ATTR cardiac amyloidosis: Feasibility and correlation with visual scores.
- Authors
Caobelli, Federico; Braun, Martin; Haaf, Philip; Wild, Damian; Zellweger, Michael J.
- Abstract
<bold>Purpose: </bold>While a visual interpretation of 99mTc-DPD scintigraphy by means of Perugini score can provide a reliable diagnosis of transthyretin-related (ATTR) cardiac amyloidosis (CA), a quantitative approach is expected to play a major role in risk stratification and therapy evaluation. The aim of our study was to test the feasibility of a quantitative assessment and to correlate various parameters to Perugini score.<bold>Methods: </bold>in this retrospective study, consecutive patients underwent a 99mTc-DPD whole-body bone scintigraphy and a SPECT/CT of the thorax. XSPECT-QUANT software was used to quantify the DPD uptake in the heart.<bold>Results: </bold>Thirteen patients were included. CA was confirmed in 8 and rejected in 5. Myocardial SUVmax and SUVpeak showed a fairly strong correlation with Perugini score (both ρ = .71, P = .006). Same held true for to-bone normalized values (both ρ = .75, P = .003). There was a great degree of overlap for quantitative values in patients with Perugini score 2 and 3.<bold>Conclusion: </bold>Quantitative 99mTc-DPD SPECT/CT in suspected ATTR CA patients is feasible and allows for a more accurate assessment of myocardial uptake.
- Subjects
CARDIAC amyloidosis; SINGLE-photon emission computed tomography; RADIONUCLIDE imaging; BONES; CARDIOGRAPHIC tomography; TALLIES
- Publication
Journal of Nuclear Cardiology, 2020, Vol 27, Issue 5, p1456
- ISSN
1071-3581
- Publication type
journal article
- DOI
10.1007/s12350-019-01893-8