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- Title
Adsorption Capacity and Biological Activity of Synthetic Zeolites.
- Authors
Ul'yanova, N. Yu.; Brazovskaya, E. Yu.; Golubeva, O. Yu.; Shamova, O. V.
- Abstract
The study investigates the physicochemical, porous/textural, and adsorptive properties, as well as the biological activity of BEA, RHO, PAU, and FAU(Y) synthetic zeolites. The adsorption capacity of the zeolites for oxytocin, lysozyme, and albumin—markers of low- and medium-molecular-weight pathological proteins—was measured. The concentration-dependent effects of the zeolites on the viability of human endothelial cells (Ea.hy926) were evaluated. At concentrations of 2.5 to 10 mg/mL, the Y zeolite was found to exhibit no pronounced cytotoxicity. In the presence of the BEA, the cell viability decreased to 80% even at 2.5 mg/mL. The RHO and PAU were shown to have the highest cytotoxicity and significantly inhibit the growth of human cells (down to 23–35%). The study demonstrated that only BEA and Y, among the synthetic zeolites tested, have good biomedical potential due to their high adsorption capacity, low hemolytic activity, and low cytotoxicity.
- Subjects
ADSORPTION capacity; ZEOLITES; ZEOLITE Y; CYTOTOXINS; LYSOZYMES; ENDOTHELIAL cells
- Publication
Petroleum Chemistry, 2023, Vol 63, Issue 7, p790
- ISSN
0965-5441
- Publication type
Article
- DOI
10.1134/S096554412305002X