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- Title
In utero exposure to radiation and haematological malignancies: pooled analysis of Southern Urals cohorts.
- Authors
Schüz, Joachim; Deltour, Isabelle; Krestinina, Lyudmila Y; Tsareva, Yulia V; Tolstykh, Evgenia I; Sokolnikov, Mikhail E; Akleyev, Alexander V; Schüz, Joachim
- Abstract
<bold>Background: </bold>It is scientifically uncertain whether in utero exposure to low-dose ionising radiation increases the lifetime risk of haematological malignancies.<bold>Methods: </bold>We pooled two cohorts from the Southern Urals comprising offspring of female workers of a large nuclear facility (the Mayak Production Association) and of women living in areas along the Techa River contaminated by nuclear accidents/waste from the same facility, with detailed dosimetry.<bold>Results: </bold>The combined cohort totalled 19 536 subjects with 700 504 person-years at risk over the period of incidence follow-up, and slightly more over the period of mortality follow-up, yielding 58 incident cases and 36 deaths up to age 61 years. Risk was increased in subjects who received in utero doses of ⩾80 mGy (excess relative risk (ERR): 1.27; 95% confidence interval (CI): -0.20 to 4.71), and the risk increased consistently per 100 mGy of continuous exposure in utero (ERR: 0.77; CI: 0.02 to 2.56). No association was apparent in mortality-based analyses. Results for leukaemia and lymphoma were similar. A very weak positive association was observed between incidence and postnatal exposure.<bold>Conclusions: </bold>In summary, the results suggest a positive association between in utero exposure to ionising radiation and risk of haematological malignancies, but the small number of outcomes and inconsistent incidence and mortality findings preclude firm conclusions.
- Subjects
RUSSIA; LONGITUDINAL method; NUCLEAR reactors; RADIATION; RADIATION doses; RADIATION carcinogenesis; RESEARCH funding; OCCUPATIONAL hazards; ENVIRONMENTAL exposure; DISEASE incidence; HEMATOLOGIC malignancies; PRENATAL exposure delayed effects
- Publication
British Journal of Cancer, 2017, Vol 116, Issue 1, p126
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/bjc.2016.373