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- Title
Effect of hepatic arterial infusion chemotherapy of 5-fluorouracil and cisplatin for advanced hepatocellular carcinoma in the Nationwide Survey of Primary Liver Cancer in Japan.
- Authors
Nouso, K; Miyahara, K; Uchida, D; Kuwaki, K; Izumi, N; Omata, M; Ichida, T; Kudo, M; Ku, Y; Kokudo, N; Sakamoto, M; Nakashima, O; Takayama, T; Matsui, O; Matsuyama, Y; Yamamoto, K; Liver Cancer Study Group of Japan
- Abstract
<bold>Background: </bold>The efficacy of hepatic arterial infusion chemotherapy for the treatment of advanced hepatocellular carcinoma (HCC) remains unclear.<bold>Methods: </bold>The outcome of 476 patients with HCC who underwent hepatic arterial infusion chemotherapy with 5-fluorouracil and cisplatin (HAIC) were compared with 1466 patients who did not receive active therapy.<bold>Results: </bold>A survival benefit of the therapy after adjusting for known risk factors was observed (hazard ratio, 0.48; 95% CI, 0.41-0.56; P<0.0001). In propensity score-matched analysis (n=682), median survival time was longer for patients who underwent chemotherapy (14.0 months) than for patients who did not receive active treatment (5.2 months, P<0.0001).<bold>Conclusion: </bold>For advanced HCC, HAIC is considered to be an effective treatment.
- Publication
British Journal of Cancer, 2013, Vol 109, Issue 7, p1904
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/bjc.2013.542