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- Title
The use of thalidomide in the management of bleeding from a gastric cancer.
- Authors
Lambert, K.; Ward, J.
- Abstract
Medical management of severe gastrointestinal bleeding can present a therapeutic challenge. We describe a case of bleeding secondary to gastric cancer that failed to settle, despite treatment with tranexamic acid, etamsylate and sucralfate. Thalidomide was prescribed for its antiangiogenic properties. Bleeding settled within 1 week of starting 300 mg of thalidomide nocte. The effect appeared to be dose dependant, with bleeding recurring only when the dose was reduced to 100 mg of thalidomide nocte.
- Subjects
GASTROINTESTINAL hemorrhage; GASTRIC diseases; THALIDOMIDE; SUCRALFATE; CANCER
- Publication
Palliative Medicine, 2009, Vol 23, Issue 5, p473
- ISSN
0269-2163
- Publication type
Article
- DOI
10.1177/0269216309102526