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- Title
Development of Gold-Coated Magnetic Nanoparticles as a Potential MRI Contrast Agent.
- Authors
Montazerabadi, Ali Reza; Oghabian, Mohammad Ali; Irajirad, Rasoul; Muhammadnejad, Samad; Ahmadvand, Davoud; Delavari H, Hamid; Mahdavi, Seyed Rabie
- Abstract
Gold-coated superparamagnetic iron oxide nanoparticles (SPIONs) coated with methyl-polyethylene glycol (mPEG) are synthesized and investigated as a magnetic resonance (MR) imaging contrast agent. The synthesized mPEG-core@shells are characterized by UV-visible spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), vibrating sample magnetometry (VSM), zeta-potential analysis and X-ray diffraction (XRD). In addition, the transverse relaxivity of the mPEG-core@shells is measured using a 3 T MRI scanner. The cytotoxicity of the mPEG-core@shells is tested in the LNCaP cell line using an 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results show that the mPEG-core@shell particles are semispherical with hydrodynamic size of ∼ 65 nm and a transverse relaxivity of 162.3 mM-1 S-1. The mPEG-core@shell particles demonstrate good stability in biological media without any significant in vitro cytotoxicity under high cellular uptake conditions. Finally, in vivo imaging shows that mPEG-core@shells are a potential contrast agent for use in early-stage detection. Gold-coated superparamagnetic iron oxide nanoparticles (SPIONs) coated with methylpolyethylene glycol (mPEG) were synthesized and characterized. The transverse relaxivity of the nanocomplex was measured of 162.3 mM-1S-1. The nanocomplex demonstrated good stability in biological media without any significant in vitro cytotoxicity under high cellular uptake conditions. Finally, in vivo imaging showed that nanocomplex is a potential contrast agent for MRI.
- Subjects
GOLD coatings; MAGNETIC nanoparticles; CONTRAST media; MAGNETIC resonance imaging; SUPERPARAMAGNETIC materials; IRON oxide nanoparticles; POLYETHYLENE glycol
- Publication
NANO, 2015, Vol 10, Issue 4, p-1
- ISSN
1793-2920
- Publication type
Article
- DOI
10.1142/S1793292015500484