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- Title
Evidence that stainable bone marrow iron following parenteral iron therapy does not correlate with serum iron studies and may not represent readily available storage iron.
- Authors
Ronald W Thomason; Muhamad S Almiski
- Abstract
We recently reported that parenteral iron therapy is associated with a characteristic pattern of iron staining on bone marrow aspirate smears. We now present clinical information from 6 patients who received parenteral iron and, at one or more points in follow-up, were found to have low or borderline low serum ferritin levels and/or serum iron levels, even though marrow aspirate smears revealed abundant stainable iron in the pattern characteristic of prior parenteral iron therapy. We conclude that stainable iron seen in this pattern does not correlate with serum iron studies and may not represent functionally available storage iron. This pattern of iron staining should not be used as evidence to withhold further iron therapy in patients who otherwise continue to have features of iron deficiency anemia.
- Subjects
THERAPEUTIC use of metals; PHYSIOLOGICAL effects of iron; BONE marrow; PARENTERAL feeding; SERUM; FERRITIN; IRON deficiency diseases; ANEMIA
- Publication
American Journal of Clinical Pathology, 2009, Vol 131, Issue 4, p580
- ISSN
0002-9173
- Publication type
Article
- DOI
10.1309/AJCPBAY9KRZF8NUC