We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Phase II study of 5-fluorouracil/leucovorin for pediatric patients with malignant solid tumors.
- Authors
Pratt, Charles B.; Meyer, William H.; Howlett, Nanna; Douglass, Edwin C.; Bowman, Laura C.; Poe, Debbie; Mounce, Kevin; Kun, Larry E.; Houghton, Janet A.; Pratt, C B; Meyer, W H; Howlett, N; Douglass, E C; Bowman, L C; Poe, D; Mounce, K; Kun, L E; Houghton, J A
- Abstract
<bold>Background: </bold>5-Fluorouracil (5-FU) activity for various carcinomas of adults has been enhanced through the synergistic effect of leucovorin. Few pediatric studies of 5-FU in pediatric patients have been previously reported.<bold>Methods: </bold>Fifty-eight patients were treated with a 4-hour infusion of leucovorin, 400 mg/m2, administered daily for 5 days every 3-4 weeks. 5-Fluorouracil was administered by bolus injection 1 hour into each leucovorin infusion. Eleven adolescent patients with colorectal carcinoma, Stage 3 or 4, were treated with therapeutic intent, and other patients with a variety of drug-resistant pediatric solid neoplasms received similar treatment.<bold>Results: </bold>Patients with measurable disease of colorectal carcinoma responded favorably to 5-FU/leucovorin. Stable disease activity was seen with other tumor types. Specifically, there were no objective responses in 12 patients with Ewing's Sarcoma or 11 with osteosarcoma. There were 4 deaths in this study from causes related to toxicity. Nonfatal grade 3/4 toxicities included mucositis, rash, myelosuppression, nausea, vomiting, diarrhea, and infection.<bold>Conclusion: </bold>The authors do not plan further evaluation of 5-FU/leucovorin in additional pediatric patients with colon cancer or other heavily pretreated malignant solid tumors and are presently treating their patients with colon carcinoma with 5-FU/leucovorin/interferon-alpha 2a.
- Publication
Cancer (0008543X), 1994, Vol 74, Issue 9, p2593
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19941101)74:9<2593::AID-CNCR2820740930>3.0.CO;2-C