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- Title
Immunohistochemical study of estrogen receptors and the responsiveness to estrogen in papillary thyroid carcinoma.
- Authors
Inoue, Hiroyuki; Oshimo, Kazushi; Miki, Hitoshi; Kawano, Muneo; Monden, Yasumasa; Inoue, H; Oshimo, K; Miki, H; Kawano, M; Monden, Y
- Abstract
<bold>Background: </bold>Epidemiologic data suggested that the differentiated thyroid carcinoma was affected by sex hormones, especially estrogen.<bold>Methods: </bold>The authors have immunohistochemically studied estrogen receptors (ER) in papillary thyroid carcinoma in women. Two anti-ER monoclonal antibodies, D5 and H222, were used. The authors then investigated the responsiveness to estrogen of thyroid neoplasms using primary culture of surgically resected thyroid tissues. The proliferative activity of cultured cells was measured by the bromodeoxyuridine (BrdU) labeling index (LI).<bold>Results: </bold>Twenty-six percent of the specimens (18/70) showed positive staining with D5, but only 5.6% of the specimens (2/36) showed positive staining with H222. The BrdU LI of ER-positive papillary thyroid carcinoma increased with the addition of estradiol.<bold>Conclusions: </bold>These findings indicate that estrogen may affect the proliferation of ER-positive papillary thyroid carcinoma.
- Subjects
PROTEIN analysis; CELL culture; ESTRADIOL; THYROID gland tumors; PAPILLARY carcinoma; IMMUNOHISTOCHEMISTRY; DEOXYRIBONUCLEOSIDES; MONOCLONAL antibodies; PSYCHOLOGICAL tests
- Publication
Cancer (0008543X), 1993, Vol 72, Issue 4, p1364
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19930815)72:4<1364::AID-CNCR2820720435>3.0.CO;2-2