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- Title
Composite Hodgkin's and non-Hodgkin's lymphoma in a patient with acquired immune deficiency syndrome. In-situ demonstration of Epstein-Barr virus.
- Authors
Guarner, Jeannette; Rio, Carlos Del; Hendrix, Lynn; Unger, Elizabeth R.; Guarner, J; del Rio, C; Hendrix, L; Unger, E R
- Abstract
A 44-year-old man infected with human immunodeficiency virus had Hodgkin's disease, mixed cellularity, and malignant non-Hodgkin's lymphoma, diffuse large cell type. Colorimetric in-situ hybridization showed the Epstein-Barr virus (EBV) genome in the cells of the large cell non-Hodgkin's lymphoma and in the Reed-Sternberg cells and reactive lymphocytes of the Hodgkin's lymphoma. These results suggest that EBV may play a similar causative role in both neoplasms. This colorimetric method of hybridization, yielding results within 8 hours, is applicable to archival material and will be useful in further epidemiologic work associating EBV and lymphoid proliferations and malignancies.
- Publication
Cancer (0008543X), 1990, Vol 66, Issue 4, p796
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19900815)66:4<796::AID-CNCR2820660433>3.0.CO;2-U