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- Title
The global burden of pulmonary hypertension in sickle cell disease: a systematic review and meta-analysis.
- Authors
Musa, B.; Galadanci, N.; Coker, M.; Bussell, S.; Aliyu, M.; Musa, B M; Galadanci, N A; Aliyu, M H
- Abstract
Elevated tricuspid regurgitant jet velocity (TRJV) is a surrogate measure of pulmonary hypertension (PH) in persons with sickle cell disease (SCD). We sought to estimate the burden of PH in people living with sickle cell disease based on TRJV. From 2000 to 2015, we searched electronic databases for eligible publications and included 29 studies (n = 5358 persons). We used random effects modeling to determine the pooled estimate of elevated TRJV. The overall pooled prevalence of elevated TRJV was 23.5 %(95 % CI 19.5-27.4) in persons with SCD. The pooled prevalence of elevated TRJV in children and adults with SCD was 20.7 % (95 % CI 15.7--25.6) and 24.4 % (95 % CI 18.4-30.4), respectively. TRJV is prevalent among adults and children with SCD. Our finding support international recommendations that call for screening for PH in SCD patients.
- Subjects
PULMONARY hypertension diagnosis; TRICUSPID valve abnormalities; SICKLE cell anemia; AORTIC valve insufficiency; SOCIAL conditions in Africa; META-analysis; PATIENTS; BIOLOGICAL models; DEMOGRAPHY; DOPPLER echocardiography; EPIDEMIOLOGICAL research; HEART valve diseases; PULMONARY hypertension; SYSTEMATIC reviews; DISEASE prevalence; DISEASE complications
- Publication
Annals of Hematology, 2016, Vol 95, Issue 11, p1757
- ISSN
0939-5555
- Publication type
journal article
- DOI
10.1007/s00277-016-2693-z