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- Title
Microscopic Colitis Is Not an Independent Risk Factor for Low Bone Density.
- Authors
Graziano, Elliot J.; Vaughn, Byron P.; Wang, Qi; Chow, Lisa S.; Campbell, James P.
- Abstract
Background: Microscopic colitis (MC) is a subtype of inflammatory bowel disease (IBD) with overlapping risk factors for low bone density (LBD). While LBD is a known complication of IBD, its association with MC is not well-established. Aims: Assess the prevalence of LBD in MC compared to control populations, and evaluate if MC predicts LBD when controlling for confounders. Methods: Retrospective, observational case control study of adult patients with pathologically confirmed MC from 2005 to 2015. Bone density measurements were abstracted from dual-energy X-ray absorptiometry (DEXA) reports, and bone density was classified using T-score: normal (T ≥ − 1.0), osteopenia (− 1.0 > T > -2.5) or osteoporosis (T ≤ − 2.5). Demographics, disease, medication history and LBD risk factors were obtained from chart review. Prevalence of LBD was compared to national and local controls. A matched control cohort to MC patients without prior diagnosis of LBD was analyzed with logistic regression to assess the relationship of MC to LBD. Results: One hundred and eighteen patients with MC were identified. Osteopenia in women with MC was more prevalent compared to national controls (67% vs. 49%, p = 0.0004), and LBD was more prevalent in MC patients compared to local controls (82% vs. 55%, p < 0.0001). In MC patients without prior diagnosis of LBD matched to controls, there was a higher prevalence of osteopenia (53.2% vs. 36.7%, p = 0.04). However, after controlling for confounders, MC was not associated with LBD (OR 0.83, 95% CI 0.22, 3.16, p = 0.8). Conclusions: While LBD was more prevalent in MC patients compared to control populations, with adjustment for key confounders (including BMI, steroids, smoking, vitamin D and calcium use), MC was not an independent predictor of LBD.
- Subjects
BONE density; BONE densitometry; COLITIS; DUAL-energy X-ray absorptiometry; INFLAMMATORY bowel diseases; OSTEOPOROSIS; LUMBAR vertebrae
- Publication
Digestive Diseases & Sciences, 2021, Vol 66, Issue 10, p3542
- ISSN
0163-2116
- Publication type
Article
- DOI
10.1007/s10620-020-06651-2