We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Ghrelin levels are reduced in prepubertal epileptic children under treatment with carbamazepine or valproic acid.
- Authors
Prodam, Flavia; Bellone, Simonetta; Casara, Gianluca; De Rienzo, Francesca; Grassino, Erica C.; Bonsignori, Ilaria; Demarchi, Irene; Rapa, Anna; Radetti, Giorgio; Bona, Gianni
- Abstract
A relationship between ghrelin and epilepsy has been already shown in humans, although the results are controversial. Ghrelin levels are reduced in obesity. Epileptic patients progressively develop a therapy-linked weight gain; however, the mechanisms for this have not been fully explained. The aim of our study is to evaluate if ghrelin secretion is modulated by treatment with carbamazepine or valproic acid in young prepubertal epileptic children. Ghrelin levels were reduced in normal-weight young epileptic prepubertal children under treatment with carbamazepine (p < 0.0001) or valproic acid (p < 0.006) compared to healthy age- and weight-matched subjects. Ghrelin was also lower in children under carbamazepine when compared to those under valproic acid (p < 0.01). A derangement in ghrelin secretion in epilepsy during specific pharmacologic therapies and independent of weight gain could be hypothesized.
- Subjects
GHRELIN; EPILEPSY; OBESITY; PEOPLE with epilepsy; VALPROIC acid; CARBAMAZEPINE; CHILDREN with epilepsy; THERAPEUTICS
- Publication
Epilepsia (Series 4), 2010, Vol 51, Issue 2, p312
- ISSN
0013-9580
- Publication type
Article
- DOI
10.1111/j.1528-1167.2009.02307.x