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- Title
Histopathologic and Molecular Aspects of CD56<sup>+</sup> Natural Killer/ T-Cell Lymphoma of the Testis.
- Authors
Ornstein, Deborah L.; Bifulco, Carlo B.; Braddock, Demetrios T.; Howe, John G.
- Abstract
Primary nasal-type natural killer/T-cell lymphoma of the testis is a rare malignancy. Although dissemination to the testis from other sites occurs somewhat more frequently than a primary presentation, even secondary testicular involvement is uncommon. In this article, the authors report on the comprehensive histopathologic, immunohistochemical, and molecular analysis of a case of primary testicular nasal-type natural killer/T-cell lymphoma, and review the features of 16 previously reported patients. The investigation carried out in this study indicates that the testicular nasal-type natural killer/T-cell lymphomas occur at a younger age than their B-cell counterparts, express cytoplasmic CD3 and surface CD56, and consistently show an infection by Epstein-Barr virus. These tumors have variable expression of T-cell antigens other than cytoplasmic CD3 and may show monoclonal rearrangement of T-cell receptor genes. Testicular natural killer/T-cell lymphomas of nasal type invariably follow an aggressive clinical course.
- Subjects
LYMPHOPROLIFERATIVE disorders; TESTICULAR cancer; IMMUNOCHEMISTRY; EPSTEIN-Barr virus; CELL receptors; MEDICAL research
- Publication
International Journal of Surgical Pathology, 2008, Vol 16, Issue 3, p291
- ISSN
1066-8969
- Publication type
Article
- DOI
10.1177/1066896907309687