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- Title
Bimodal Fluorescence and Magnetic Resonance Imaging Using Water-Soluble Hexagonal NaYF<sub>4</sub>:Ce, Tb, Gd Nanocrystals.
- Authors
Wen Ting Ren; Liang Bo Liang; Fei Qi; Zheng Bo Sun; Zhi Yong Yang; Xiao Qi Huang; Qi Zhu Wu; Hong Yan Zhu; Xue Feng Yu; Hong Quan; Qi Yong Gong
- Abstract
The present study explored the feasibility of using hexagonal-phase NaYF4:Ce,Tb,Gd nanocrystals as bimodal probes for fluorescence and magnetic resonance (MR) imaging. Using a facile and user-friendly strategy, the NaYF4:Ce,Tb,Gd nanocrystals were synthesized with good water dispensability, high quantum yield (26%), and decent MR T1 relaxivity (r1 = 2.87mM-1 s-1). The NaYF4:Ce, Tb, Gd NCs conjugated by folic acid presented great efficiency in fluorescence imaging of C6 glioma cells in vitro. Meanwhile, in in vivo MR experiments on rats, the NaYF4:Ce,Tb,Gd NCs also significantly increased T1 signal in the liver, spleen, and kidney even with a low probe dose. The proposed NaYF4:Ce,Tb,Gd nanoprobes hold promise for simultaneous bimodal fluorescence and MR bioimaging.
- Subjects
FLUORESCENCE; MAGNETIC resonance imaging; NANOCRYSTALS; FOLIC acid; GLIOMAS
- Publication
Journal of Nanomaterials, 2011, p1
- ISSN
1687-4110
- Publication type
Article
- DOI
10.1155/2011/531217