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- Title
Deep eutectic solvents formed by pharmaceutical ingredients and their potential influences on solid preparations.
- Authors
TOUFOUKI, SARA; ALI, AHMAD; YOUMO WANG; RUI LI; YU CAO; SHUN YAO
- Abstract
Some active pharmaceutical ingredients (APIs) and excipients can form deep eutectic solvents (DESs), which will lead to severe defects in solid preparations. This work first prepared related typical DESs by mixing APIs and excipients from marketable drugs. Then two different types of the binary eutectic mixtures were investigated, which were composed of menthol (HBD) and citric acid (HBA), ME/CA, as well as phenyl salicylate (HBA) and benzoic acid (HBD), Salol/BA. These binary mixtures were applied to investigate their possible effects on capsules and tablets, which could be liquefaction or the stickiness of the solid formulations. The comprehensive characterizations and studies on phase behaviours of the binary mixtures were carried out, and the spectral analysis confirmed the formation of the eutectic liquids from individual components. Furthermore, the binary mixtures have increased the tablet strength when increasing the compression force, leading to the stickiness of powders during pressing. Moreover, the capsules were softened by the existence of DESs. After morphological observation and quantitative analysis, the corresponding suggestions and countermeasures were provided in the conclusions.
- Subjects
BINARY mixtures; EUTECTICS; BENZOIC acid; SOLVENTS; CITRIC acid; MENTHOL; EXCIPIENTS
- Publication
Journal of the Serbian Chemical Society, 2024, Vol 89, Issue 1, p107
- ISSN
0352-5139
- Publication type
Article
- DOI
10.2298/JSC230825099T