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- Title
Untargeted Metabolomics Reveals Intervention Effects of Total Turmeric Extract in a Rat Model of Nonalcoholic Fatty Liver Disease.
- Authors
Wang, Ya; Niu, Ming; Jia, Ge-liu-chang; Li, Rui-sheng; Zhang, Ya-ming; Zhang, Cong-en; Meng, Ya-kun; Cui, He-rong; Ma, Zhi-jie; Li, Dong-hui; Wang, Jia-bo; Xiao, Xiao-he
- Abstract
Nonalcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease. Currently, there are no recognized medical therapies effective for NAFLD. Previous studies have demonstrated the effects of total turmeric extract on rats with NAFLD induced by high-fat diet. In this study, serum metabolomics was employed using UHPLC-Q-TOF-MS to elucidate the underlying mechanisms of HFD-induced NAFLD and the therapeutic effects of TE. Supervised orthogonal partial least-squares-discriminant analysis was used to discover differentiating metabolites, and pathway enrichment analysis suggested that TE had powerful combined effects of regulating lipid metabolism by affecting glycerophospholipid metabolism, glycerolipid metabolism, and steroid hormone biosynthesis signaling pathways. In addition, the significant changes in glycerophospholipid metabolism proteins also indicated that glycerophospholipid metabolism might be involved in the therapeutic effect of TE on NAFLD. Our findings not only supply systematic insight into the mechanisms of NAFLD but also provide a theoretical basis for the prevention or treatment of NAFLD.
- Subjects
LIPID metabolism; THERAPEUTIC use of plant extracts; ANIMAL experimentation; BIOLOGICAL models; CELLULAR signal transduction; DISCRIMINANT analysis; FATTY liver; RATS; STEROIDS; PLANT extracts; TURMERIC; THERAPEUTICS
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2016, Vol 2016, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2016/8495953