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- Title
Roles of unphosphorylated STATs in signaling.
- Authors
Jinbo Yang; Stark, George R.
- Abstract
The seven members of the signal transducer and activator of transcription (STAT) family of transcription factors are activated in response to many different cytokines and growth factors by phosphorylation of specific tyrosine residues. The STAT1 and STAT3 genes are specific targets of activated STATs 1 and 3, respectively, resulting in large increases in the levels of these unphosphorylated STATs (U-STATs) in response to the interferons (STAT1) or ligands that active gp130, such as IL-6 (STAT3). U-STATs drive gene expression by novel mechanisms distinct from those used by phosphorylated STAT (P-STAT) dimers. In this review, we discuss the roles of U-STATs in transcription and regulation of gene expression.Cell Research (2008) 18:443–451. doi: 10.1038/cr.2008.41: published online 25 March 2008
- Subjects
TRANSDUCERS; TRANSCRIPTION factors; ELECTROMECHANICAL devices; ELECTRIC equipment; ANTIVIRAL agents
- Publication
Cell Research, 2008, Vol 18, Issue 4, p443
- ISSN
1001-0602
- Publication type
Article
- DOI
10.1038/cr.2008.41