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- Title
Chemical Structure, Hypoglycemic Activity, and Mechanism of Action of Selenium Polysaccharides.
- Authors
Duan, Wen-Xia; Yang, Xiao-Hua; Zhang, Hua-Feng; Feng, Jing; Zhang, Meng-Yuan
- Abstract
Selenium polysaccharides (Se-polysaccharides) are one of important forms of organic Se, in which selenium (Se) and polysaccharides are joined by covalent bonds. In the present review, recent progress in chemical structure and hypoglycemic activity of Se-polysaccharides is summarized. In particular, the mechanism underlying hypoglycemic capacity of Se-polysaccharides is discussed, and the relationship between hypoglycemic activity and chemical structure is analyzed. Besides, strategies for further research into chemical structure and hypoglycemic activity of Se-polysaccharides are proposed. Hypoglycemic activity of Se-polysaccharides is closely related to their inhibitory effect on α-amylase and α-glucosidase, influence on insulin signal pathway especially IRS-PI3K-Akt signaling pathway, and protection capacity against oxidative stress.
- Subjects
CHEMICAL structure; POLYSACCHARIDES; SELENIUM; INSULIN receptors; COVALENT bonds; CELLULAR signal transduction; DIGESTIVE enzymes; ALPHA-glucosidases
- Publication
Biological Trace Element Research, 2022, Vol 200, Issue 10, p4404
- ISSN
0163-4984
- Publication type
Article
- DOI
10.1007/s12011-021-03035-z