We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Selenium Supplementation Protects Against Lipopolysaccharide-Induced Heart Injury via Sting Pathway in Mice.
- Authors
Wang, Xuan; Yang, Bin; Cao, Hui-Li; Wang, Rui-Ying; Lu, Zhao-Yang; Chi, Rui-Fang; Li, Bao
- Abstract
Sepsis-induced myocardial dysfunctions are associated with high morbidity and mortality. Selenium, an essential trace element, has been reported to exert anti-inflammation, anti-oxidative stress, and anti-apoptosis. However, the protective effects of selenium on LPS-induced heart injury are still poorly illustrated. Therefore, in the present study, we sought to explore the effects of selenium pretreatment on LPS-induced myocardial injury in mice. We firstly found that selenium pretreatment significantly improved markers of myocardial injury and alleviated LPS-induced myocardial dysfunctions. Moreover, selenium supplementation reduced pro-inflammatory cytokines expression, decreased oxidative stress, and inhibited myocardial apoptosis. In addition, selenium supplementation inactivated the Sting pathway. In conclusion, our study suggests that selenium exerts protective effects on LPS-induced myocardial injury, and the underlying molecular mechanism may be related to the inactivation of Sting pathway, implying a potential therapy for sepsis-induced myocardial dysfunctions.
- Subjects
HEART injuries; SELENIUM; TRACE elements; MICE; OXIDATIVE stress; SEPSIS
- Publication
Biological Trace Element Research, 2021, Vol 199, Issue 5, p1885
- ISSN
0163-4984
- Publication type
Article
- DOI
10.1007/s12011-020-02295-5