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- Title
N-terminal [Glu]<sub>3</sub> moiety of γ-glutamyl peptides contributes largely to the activation of human calcium-sensing receptor, a kokumi receptor.
- Authors
Yamamoto, Mizuki; Terada, Yuko; Motoyama, Takayasu; Shibata, Munehisa; Saito, Tsutomu; Ito, Keisuke
- Abstract
γ-glutamyl peptides have been suggested to impart kokumi properties to foods by activating human calcium-sensing receptor (hCaSR). In this study, the relationship between γ-glutamyl peptide structure and hCaSR activity was systematically analyzed using γ-[Glu](n=0-4)-α-[Glu](n=0-3)-Tyr. Our results suggest that N-terminal [Glu]3 moiety is very important for hCaSR activities of γ-glutamyl peptides.
- Subjects
CALCIUM-sensing receptors; MOIETIES (Chemistry); PEPTIDES; STRUCTURE-activity relationships; RYANODINE receptors; GAMMA-glutamyltransferase
- Publication
Bioscience, Biotechnology & Biochemistry, 2020, Vol 84, Issue 7, p1497
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2020.1743169