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- Title
Effect of dietary cellulose nanofiber and exercise on obesity and gut microbiota in mice fed a high-fat-diet.
- Authors
Nagano, Takao; Yano, Hiromi
- Abstract
Cellulose nanofiber (CN) consumption with exercise could be a potential strategy to control obesity. Here, we studied the effects of CN supplementation and voluntary exercise on obesity and gut microbiota in high-fat diet (HFD)-fed mice. Consumption of CN increased voluntary wheel running activity. CN intake and exercise together suppressed the increase in body weight and fat mass, and improved glucose tolerance. The fecal gut microbiota was analyzed by sequencing 16S ribosomal RNA genes. Principal component analysis revealed a shift in the microbiota composition resulting from exercise, but not from CN supplementation. Erysipelotrichaceae and Rikenellaceae decreased with exercise. Exercise also increased Ruminococcaceae, whereas exercise and CN intake together increased Eubacteriaceae. These two families are butyrate producers. Exercise increased the amount of acetate in the cecum. These results suggest that CN consumption improves exercise performance and exerts anti-obesity effects by modulating the balance of the gut microbiota. CN intake improves exercise performance and suppresses obesity by controlling the balance of the gut microbiota.
- Subjects
GUT microbiome; EXERCISE tolerance; BODY composition; CELLULOSE; EXERCISE; OBESITY; CHILDHOOD obesity
- Publication
Bioscience, Biotechnology & Biochemistry, 2020, Vol 84, Issue 3, p613
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2019.1690975