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- Title
Immunostimulatory effect on dendritic cells of the adjuvant-active exopolysaccharide from Leuconostoc mesenteroides strain NTM048.
- Authors
Matsuzaki, Chiaki; Takagaki, Chikahiro; Higashimura, Yasuki; Nakashima, Yukari; Hosomi, Koji; Kunisawa, Jun; Yamamoto, Kenji; Hisa, Keiko
- Abstract
This study evaluated the immunostimulative effect on bone marrow-derived dendritic cells (DCs) of adjuvant-active exopolysaccharide (EPS) produced by Leuconostoc mesenteroides strain NTM048. EPS stimulation increased IL-6, IL-10, IL-12, and retinal dehydrogenase (RALDH) gene expression levels and induced retinoic acid-synthesizing RALDH-active DCs, which play a crucially important role in controlling adaptive immune responses in mucosa.
- Subjects
IMMUNOLOGICAL adjuvants; DENDRITIC cells; MICROBIAL exopolysaccharides
- Publication
Bioscience, Biotechnology & Biochemistry, 2018, Vol 82, Issue 9, p1647
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2018.1482195