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- Title
Evaluation of histological grade and histologically tumour-free margins as predictors of local recurrence in completely excised canine mast cell tumours.
- Authors
Donnelly, L.; Mullin, C.; Balko, J.; Goldschmidt, M.; Krick, E.; Hume, C.; Brown, D. C.; Sorenmo, K.
- Abstract
Completeness of mast cell tumour ( MCT) excision is determined by assessment of histologically tumour-free margins ( HTFM). The HTFM width necessary to prevent local recurrence ( LR), recognized as histologic safety margin ( HSM) in human oncology, has not been defined. We hypothesized that HTFM width would correlate with risk for LR and high-grade tumours would require wider HTFM than low-grade tumours. Records of dogs with completely excised MCTs were included. Signalment, two-tier tumour grade, tumour size, HTFM width, recurrence and therapy data was collected. High-grade ( n = 39) tumours were more likely to recur than low-grade ( n = 51) tumours (35.9% versus 3.9%), P < 0.0001, with no association between HTFM width and LR. Twenty-nine percent of low-grade tumours had HTFM less than 3 mm; none recurred. Narrow (≤3 mm) histologic margins are likely adequate to prevent LR of low-grade tumours. High-grade tumours have significant risk of LR regardless of HTFM width.
- Subjects
MAST cells; HISTOLOGY; TUMOR markers; BIOMARKERS; DISEASE risk factors
- Publication
Veterinary & Comparative Oncology, 2015, Vol 13, Issue 1, p70
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/vco.12021