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- Title
A Dual‐Targeted Organic Photothermal Agent for Enhanced Photothermal Therapy.
- Authors
Wang, Hongyu; Chang, Jinjie; Shi, Mingwan; Pan, Wei; Li, Na; Tang, Bo
- Abstract
The development of highly effective anticancer drugs that cause minimal damage to the surrounding normal tissues is a challenging topic in cancer therapy. Herein, we demonstrate a dual‐targeted organic molecule that functions as a photothermal agent by actively targeting tumor tissue and mitochondria to selectively kill cancer cells. The synthesized photothermal agent exhibited high photothermal conversion efficiency, low cytotoxicity, and good biological compatibility. In vivo experiments showed an excellent tumor inhibitory effect of the dual‐targeted photothermal agent.
- Subjects
CANCER treatment; PHOTOTHERMAL effect; CANCER cells; ANTINEOPLASTIC agents; CELL-mediated cytotoxicity
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 4, p1069
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201811273