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- Title
Enantioselective Synthesis of (−)‐Halenaquinone.
- Authors
Goswami, Subir; Harada, Kenichi; El‐Mansy, Mohamed F.; Lingampally, Rajinikanth; Carter, Rich G.
- Abstract
Abstract: The efficient, 12–14 step (LLS) total synthesis of (−)‐halenaquinone has been achieved. Key steps in the synthetic sequence include: (a) proline sulfonamide‐catalyzed, Yamada–Otani reaction to establish the C6 all‐carbon quaternary stereocenter, (b) multiple, novel palladium‐mediated oxidative cyclizations to introduce the furan moiety, and (c) oxidative Bergman cyclization to form the final quinone ring.
- Subjects
PALLADIUM; FURAN derivatives; SULFONAMIDES
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 29, p9255
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201805370