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- Title
Design, Synthesis, and Application of Chiral <italic>C</italic><sub>2</sub>‐Symmetric Spiroketal‐Containing Ligands in Transition‐Metal Catalysis.
- Authors
Argüelles, Alonso J.; Sun, Siyuan; Budaitis, Brenna G.; Nagorny, Pavel
- Abstract
Abstract: We present an expedient and economical route to a new spiroketal‐based C2‐symmetric chiral scaffold, termed SPIROL. Based on this spirocyclic scaffold, several chiral ligands were generated. These ligands were successfully employed in an array of stereoselective transformations, including in iridium‐catalyzed hydroarylations (up to 95 % <italic>ee</italic>), palladium‐catalyzed allylic alkylations (up to 97 % <italic>ee</italic>), intermolecular palladium‐catalyzed Heck couplings (up to 94 % <italic>ee</italic>), and rhodium‐catalyzed dehydroalanine hydrogenation (up to 93 % <italic>ee</italic>).
- Subjects
LIGANDS (Chemistry); CHIRALITY; CATALYSIS; CHEMICAL synthesis; STEREOSELECTIVE reactions; ARYLATION
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 19, p5423
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201713304