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- Title
Copper-Catalyzed Synthesis and Applications of Yndiamides.
- Authors
Mansfield, Steven J.; Christensen, Kirsten E.; Thompson, Amber L.; Ma, Kai; Jones, Michael W.; Mekareeya, Aroonroj; Anderson, Edward A.
- Abstract
The first synthetic route to yndiamides, a novel class of double aza-substituted alkyne, has been established by the copper(I)-catalyzed cross-coupling of 1,1-dibromoenamides with nitrogen nucleophiles. The utility of these compounds is demonstrated in a range of transition-metal-catalyzed and acid-catalyzed transformations to afford a wide variety of 1,2-diamide functionalized products.
- Subjects
COPPER catalysts; AMIDE synthesis; ALKYNES; NUCLEOPHILES; ACID catalysts
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 46, p14620
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201706915