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- Title
Covalent Self-Assembly and One-Step Photocrosslinking of Tyrosine-Rich Oligopeptides to Form Diverse Nanostructures.
- Authors
Min, Kyoung‐Ik; Yun, Gyeongwon; Jang, Yoonjung; Kim, Kyung‐Rok; Ko, Young Ho; Jang, Hyung‐Seok; Lee, Yoon‐Sik; Kim, Kimoon; Kim, Dong‐Pyo
- Abstract
We present covalently self-assembled peptide hollow nanocapsule and peptide lamella. These biomimetic dityrosine peptide nanostructures are synthesized by one-step photopolymerization of a tyrosine-rich short peptide without the aid of a template. This simple approach offers direct synthesis of fluorescent peptide nanocages and free-standing thin films. The simple crosslinked peptide lamella films provide robust mechanical properties with an elastic modulus of approximately 30 GPa and a hardness of 740 MPa. These nanostructures also allow for the design of peptidosomes. The approach taken here represents a rare example of covalent self-assembly of short peptides into nano-objects, which may be useful as microcompartments and separation membranes.
- Subjects
MOLECULAR self-assembly; PHOTOCROSSLINKING; TYROSINE; OLIGOPEPTIDES; NANOPARTICLE synthesis; MEMBRANE separation; PHOTOPOLYMERIZATION
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 24, p7039
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201601675