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- Title
Merging Photoredox and Nickel Catalysis: The Direct Synthesis of Ketones by the Decarboxylative Arylation of α-Oxo Acids.
- Authors
Chu, Lingling; Lipshultz, Jeffrey M.; MacMillan, David W. C.
- Abstract
The direct decarboxylative arylation of α-oxo acids has been achieved by synergistic visible-light-mediated photoredox and nickel catalysis. This method offers rapid entry to aryl and alkyl ketone architectures from simple α-oxo acid precursors via an acyl radical intermediate. Significant substrate scope is observed with respect to both the oxo acid and arene coupling partners. This mild decarboxylative arylation can also be utilized to efficiently access medicinal agents, as demonstrated by the rapid synthesis of fenofibrate.
- Subjects
ARYLATION; TRANSITION metals; FENOFIBRATE; ANTILIPEMIC agents; PROPIONATES; ACYL radicals; ACYL group
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 27, p8040
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201501908