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- Title
Chemoenzymatic Synthesis of Spinosyn A.
- Authors
Kim, Hak Joong; Choi, Sei ‐ hyun; Jeon, Byung ‐ sun; Kim, Namho; Pongdee, Rongson; Wu, Qingquan; Liu, Hung ‐ wen
- Abstract
Following the biosynthesis of polyketide backbones by polyketide synthases (PKSs), post-PKS modifications result in a significantly elevated level of structural complexity that renders the chemical synthesis of these natural products challenging. We report herein a total synthesis of the widely used polyketide insecticide spinosyn A by exploiting the prowess of both chemical and enzymatic methods. As more polyketide biosynthetic pathways are characterized, this chemoenzymatic approach is expected to become readily adaptable to streamlining the synthesis of other complex polyketides with more elaborate post-PKS modifications.
- Subjects
SPINOSYN; BIOSYNTHESIS; POLYKETIDE synthases; NATURAL products; CHEMICAL synthesis; POLYKETIDES
- Publication
Angewandte Chemie, 2014, Vol 126, Issue 49, p13771
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201407806