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- Title
Bacillus Calmette-Guérin pneumonitis after intravesical instillation: Report of two cases and a review of the literature.
- Authors
Spisarova, Martina; Losse, Stanislav; Jakubec, Petr; Hartmann, Igor; Kra, Milan; Ehrmann, Jiri; Szkorupa, Marek; Studentova, Hana; Melichar, Bohuslav
- Abstract
Objective. Intravesical administration of bacillus Calmette-Guérin is standard adjuvant treatment of non-muscle invasive bladder cancer. In spite of the fact that this immunotherapy is locoregional, there are still risk of some complications. Methods. We describe two cases of systemic BCG infection after intravesical administration of BCG vaccine in patients with early stage of bladder cancer. Results. Both patients suffered from systemic BCG infection manifesting as BCG pneumonitis. After standard therapy with antituberculotic agents, both of them fully recovered. Conclusion. BCG infection can occur as a rare but potentially serious complication of this treatment procedure. Gravity of this side effect and its specific therapy require prompt and right diagnosis.
- Subjects
BLADDER cancer; BCG immunotherapy; INTRAVESICAL administration; LITERATURE reviews; NON-muscle invasive bladder cancer; PNEUMONIA
- Publication
Biomedical Papers of the Medical Faculty of Palacky University in Olomouc, 2024, Vol 168, Issue 2, p181
- ISSN
1213-8118
- Publication type
Case Study
- DOI
10.5507/bp.2022.051