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- Title
Post‐traumatic stress disorder and risk of osteoporosis: A nationwide longitudinal study.
- Authors
Huang, Wei‐Sheng; Hsu, Ju‐Wei; Huang, Kai‐Lin; Bai, Ya‐Mei; Li, Cheng‐Ta; Lin, Wei‐Chen; Tsai, Shih‐Jen; Liou, Ying‐Jay; Chen, Mu‐Hong; Su, Tung‐Ping; Chen, Tzeng‐Ji
- Abstract
Abstract: Several studies suggested a relationship between stress and related mental illnesses, such as depression and osteoporosis. However, it was unclear whether patients with post‐traumatic stress disorder (PTSD) were at risk of developing osteoporosis in later life. In this study, 6,041 patients with PTSD and 24,164 age‐ or sex‐matched controls were enrolled between 2002 and 2009 in our study and followed up to the end of 2011. Cases of osteoporosis were identified during the follow‐up. Patients with PTSD had an elevated likelihood of developing osteoporosis (HR: 2.66, 95% CI [1.91, 3.71]) in later life compared with the controls. Sensitivity tests after excluding the first year observation (HR: 2.46, 95% CI [1.72, 3.53]) and the first 3‐year observation (HR: 1.88, 95% CI [1.18, 3.01]) were consistent. Patients with PTSD had a higher risk of developing osteoporosis at an earlier age compared with those without PTSD. Further studies would be necessary to clarify the pathophysiology between PTSD and osteoporosis.
- Subjects
OSTEOPOROSIS; CONFIDENCE intervals; LONGITUDINAL method; POST-traumatic stress disorder; RESEARCH funding; TIME; DATA analysis software; DESCRIPTIVE statistics; DISEASE risk factors
- Publication
Stress & Health: Journal of the International Society for the Investigation of Stress, 2018, Vol 34, Issue 3, p440
- ISSN
1532-3005
- Publication type
Article
- DOI
10.1002/smi.2806