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- Title
Neurocognitive effects of switching from methylphenidate-IR to OROS-methylphenidate in children with ADHD.
- Authors
Yeni Kim; Min-Sup Shin; Jae-Won Kim; Hee-Jung Yoo; Soo-Churl Cho; Boong-Nyun Kim
- Abstract
Objectives This study evaluated neurocognitive changes after switching from immediate release forms of methylphenidate (MPH-IR) to osmotic release oral system methylphenidate (OROS-MPH). Methods 102 children with attention-deficit/hyperactivity disorder (ADHD) participated in an open label, 28 day trial, performing neurocognitive test at baseline and at 28 days after the switch from MPH-IR to OROS-MPH. Results There were significant improvements in the commission error and the reaction time of both visual and auditory continuous performance tests (CPTs) at 28 days after switching from MPH-IR to OROS-MPH. A positive correlation was observed between the improvement in parent/caregiver-rated IOWA Conners total score (Δ IOWA) and the reduction in commission error (r = 0.3, p = 0.001) and reduction in reaction time variability (r = 0.3, p = 0.006) of visual CPT. In a linear regression model, the change in parent/caregiver-rated IOWA Conners scale total scores were significant predictors of change in commission error (β = 0.3, p = 0.005, CI = 0.4–2.3, adjusted R2 = 0.12) and RT variability (β = 0.3, p = 0.004, CI = 0.5–2.4, adjusted R2 = 0.09) of visual CPT. Conclusions These data suggest that MPH-IR may be successfully switched to OROS-MPH treatment with associated improvements in neurocognitive performance. Large-scale controlled trials are needed to replicate these findings. Copyright © 2009 John Wiley & Sons, Ltd.
- Subjects
ATTENTION-deficit hyperactivity disorder; OSMOREGULATION; METHYLPHENIDATE; ACOUSTIC nerve; CHILDREN with attention-deficit hyperactivity disorder
- Publication
Human Psychopharmacology: Clinical & Experimental, 2009, Vol 24, Issue 2, p95
- ISSN
0885-6222
- Publication type
Article
- DOI
10.1002/hup.1010