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- Title
Nocturnal polyuria and nocturia relief in patients treated with solifenacin for overactive bladder symptoms.
- Authors
Linda Brubaker; Mary FitzGerald
- Abstract
Abstract  The objectives of this study are to determine whether patients with overactive bladder (OAB) and nocturia achieved relief of their nighttime voiding symptoms when treated with solifenacin and whether having nocturnal polyuria (NP) affected that response. The patients pooled from four phase III clinical trials were evaluated for reductions in nocturia episodes after treatment with solifenacin (5 or 10 mg) or placebo. A second analysis was performed in patients with and without NP. The patients treated with solifenacin experienced statistically significant reductions in nocturia episodes; median reductions were â35.5% for 5 mg of solifenacin and â36.4% for 10 mg of solifenacin compared with â25.0% for placebo, and significantly more patients treated with solifenacin vs placebo achieved a mean nocturic frequency of â¤1 episode/night. Solifenacin significantly reduced nocturia episodes only in patients without NP (mean change was â0.61 episodes/night for both doses compared with â0.43 episodes for placebo). Solifenacin significantly improved nocturia symptoms only in OAB patients without NP.
- Subjects
PLACEBOS; URINARY organs; MEDICAL experimentation on humans; CLINICAL trials
- Publication
International Urogynecology Journal, 2007, Vol 18, Issue 7, p737
- ISSN
0937-3462
- Publication type
Article
- DOI
10.1007/s00192-006-0239-y