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- Title
Computed tomography findings in ABO-incompatible living donor liver transplantation recipients with biliary strictures.
- Authors
Choi, Sang Hyun; Kim, Kyoung Won; Kim, So Yeon; Kim, Jin Sil; Kwon, Jae Hyun; Song, Gi-Won; Lee, Sung-Gyu
- Abstract
<bold>Objectives: </bold>To evaluate CT findings of biliary strictures in ABO-incompatible living donor liver transplantation (LDLT) recipients, with emphasis on associated 1-month post-transplantation CT findings, and evaluate clinical outcomes.<bold>Methods: </bold>Of 351 ABO-incompatible recipients, we retrospectively evaluated CT scans in 65 recipients with biliary stricture. The biliary strictures on CT scans were classified as type A (perihilar) and type B (diffuse). Precedent CT abnormality patterns and the presence of a periportal halo sign at 1-month post-transplantation were evaluated. For each patient, clinical outcomes were evaluated.<bold>Results: </bold>Of 65 ABO-incompatible recipients with biliary strictures, 36.9% had type B strictures. Compared with biliary strictures at diagnosis, similar CT abnormality patterns were observed for 84.4% in type A and 86.4% in type B strictures at 1-month post-transplantation. Complex periportal halo signs on the 1-month post-transplantation CT were more frequently noted for type B than type A strictures (86.4% vs. 3.1%, P < 0.001). Progressive clinical outcomes were more frequently observed for type B than type A strictures (79.2% vs. 26.8%, P < 0.001), with a significantly shorter graft survival time (46.4 months vs. 90.8 months, P < 0.001).<bold>Conclusion: </bold>CT abnormality patterns and complex periportal halo signs on 1-month post-transplantation CT may be clinically useful for managing biliary strictures in ABO-incompatible LDLT recipients. Key Points • Of ABO-incompatible LDLT recipients, type B biliary stricture incidence was 6.8%. • Of type B strictures, 86.4% exhibited similar CT abnormality patterns at 1-month post-transplantation. • Complex periportal halo at 1 month was significantly associated with type B strictures. • Progressive clinical outcomes were more frequently observed in type B strictures.
- Subjects
HEALTH outcome assessment; LIVER transplantation; SURGICAL anastomosis; HEMORRHAGE; CHEMOEMBOLIZATION; ABO blood group system; CHOLESTASIS; COMPARATIVE studies; COMPUTED tomography; GRAFT versus host reaction; RESEARCH methodology; MEDICAL cooperation; ORGAN donors; RESEARCH; SURGICAL complications; TRANSPLANTATION of organs, tissues, etc.; EVALUATION research; STENOSIS; RANDOMIZED controlled trials; RETROSPECTIVE studies; BLOOD group incompatibility; DISEASE complications
- Publication
European Radiology, 2018, Vol 28, Issue 6, p2572
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-017-5226-9