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- Title
Thermochemotherapy for Non-Muscle-Invasive Bladder Cancer: Is There a Chance to Avoid Early Cystectomy?
- Authors
Volpe, A.; Racioppi, M.; Bongiovanni, L.; D'Agostino, D.; Totaro, A.; D'Addessi, A.; Marangi, F.; Palermo, G.; Pinto, F.; Sacco, E.; Bassi, P.F.
- Abstract
Objectives: Non-muscle-invasive bladder cancer is characterized by a high recurrence rate after primary transurethral resection. In case of bacillus Calmette-Guérin-refractory neoplasms, cystectomy is the gold standard. In this study the effects of thermochemotherapy with mitomycin C were evaluated in high-risk bladder cancer nonresponders to previous therapy. Patients and Methods: Between January 2006 and December 2009, 30 patients were enrolled with recurrent stage carcinoma in situ, Ta and T1, grade G1 to G3 non-muscle-invasive bladder cancer refractory to chemotherapy or immunotherapy and so becoming suitable for radical cystectomy. All patients underwent endovesical thermochemotherapy: 16 patients underwent a prophylactic scheme and 14 patients underwent an ablative scheme. Results: All the patients completed the study. The mean follow-up for all the patients enrolled was 14 months. Thirteen of 30 patients (43.30%) were disease free and 17 patients (56.70%) had recurrence. In the prophylactic group, 7 of 16 patients (43.75%) were disease free and 9 patients (46.25%) had tumor recurrence; no progression was observed. In the ablative group, 3 patients (17, 64%) had progression to muscle-invasive disease. Side effects were generally mild. Conclusions: Thermochemotherapy could be considered an additional tool in patients refractory to intravesical therapies before considering early cystectomy. Copyright © 2012 S. Karger AG, Basel
- Subjects
BLADDER cancer treatment; CANCER chemotherapy; DISEASES in older people; CYSTECTOMY; CANCER relapse; TRANSURETHRAL prostatectomy; MITOMYCIN C
- Publication
Urologia Internationalis, 2012, Vol 89, Issue 3, p311
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000341912