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- Title
RAFT‐Polymerized N‐Cyanomethylacrylamide‐Based (Co)polymers Exhibiting Tunable UCST Behavior in Water.
- Authors
Audureau, Nicolas; Veith, Clémence; Coumes, Fanny; Nguyen, Thi Phuong Thu; Rieger, Jutta; Stoffelbach, François
- Abstract
In this present work, the synthesis of a new family of upper critical solution temperature (UCST)‐thermoresponsive polymers based on N‐cyanomethylacrylamide (CMAm) is reported. It is demonstrated that the thermally initiated reversible addition fragmentation chain transfer (RAFT) polymerization of CMAm conducted in N,N‐dimethylformamide (DMF) is well controlled. The homopolymer presents a sharp and reversible UCST‐type phase transition in pure water with a very small hysteresis between cooling and heating cycles. It is demonstrated that the cloud point (TCP) of poly(N‐cyanomethylacrylamide) (PCMAm) is strongly molar mass dependent and shifts toward lower temperatures in saline water. Moreover, the transition temperature can be tuned over a large temperature range by copolymerization of CMAm with acrylamide or acrylic acid. The latter copolymers are both thermoresponsive and pH responsive. Interestingly, by this strategy sharp and reversible UCST‐type transitions close to physiological temperature can be reached, which makes the copolymers extremely interesting candidates for biomedical applications.
- Subjects
REVERSIBLE phase transitions; THERMORESPONSIVE polymers; POLYMERS; TRANSITION temperature; ACRYLIC acid; WATER temperature
- Publication
Macromolecular Rapid Communications, 2021, Vol 42, Issue 23, p1
- ISSN
1022-1336
- Publication type
Article
- DOI
10.1002/marc.202100556